描述

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function. Note

Recombinant Human ACE2 is produced by Mammalian cells expression system and the target gene encoding Ser19-Asp615 is expressed with C-His Tag，then conjugated  to Horseradish Peroxidase

表达系统

Mammalian cells

种属

Homo sapiens (Human)

Accession #

NP_001358344.1 or Uniprot Q9BYF1

分子别名

ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,Metalloprotease MPROT15

预测分子量

71.54kDa

实际分子量

90-100kDa

纯度

>90% as determined by SDS-PAGE

内毒素

Please contact with the lab for this information

制剂

Supplied as solution form in PBS, pH7.5/ Supplied as lyophilized from PBS, pH7.5

运输方式

In general, proteins are shipped out with blue ice unless customers require otherwise.

稳定性&储存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ℃for one week . Store at -20 to -80 ℃ for twelve months from the date of receipt.

复溶

Please refer to the instraction in the hard copy of COA.

应用

Immunological test Application

ELISA,1:3000-1:6000

For research use only .Not for use in clinical diagnostic procedures.